Enhancement of compression and compaction properties of calcium carbonate powder by granulation with HPC, HPMC and sodium- alginate as binders for pharmaceutical applications: an optimization case study

01.Jun.2020

​Calcium carbonate must be processed before it can be compressed into tablets. This study examined the compression behavior of calcium carbonate powder when granulated with different binders. Hydroxypropyl cellulose (HPC), hydroxypropyl methylcellulose (HPMC) and sodium alginate (Na-Alg), were chosen at different concentrations as binding agents. Data analysis and optimization were carried out using load-displacement curves and the Kawakita model of powder compression. The viscosity of the binder solutions, the specific surface area of the granulated CaCO3 and the contact angle of the binder solutions on CaCO3 compact surfaces were used to interpret granulation behavior. Each binder interacted differently with CaCO3 with respect to powder and tablet properties. Optimum tablet processing was found to be strongly dependent on the compression pressure and concentration of the binder used. A 3% binder concentration gave the most desirable outcomes with respect to the area under the load-displacement curves (AUCs), the Kawakita parameter (Pk ) and tablet crushing strength (TCS). Calcium carbonate tablets prepared at the optimum binder concentration were stable when stored under accelerated stability conditions.

https://www.researchgate.net/publication/342215370_Enhancement_of_compression_and_compaction_properties_of_calcium_carbonate_powder_by_granulation_with_HPC_HPMC_and_sodium-_alginate_as_binders_for_pharmaceutical_applications_an_optimization_case_study​

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